London, Dec 21 (Inditop.com) Scientists have reported for the first time that a group of drugs used to treat heart failure shows promise for fighting colon cancer.
Colon cancer is the third most common cancer in the US, with more than 150,000 cases diagnosed in the country every year.
Jenny Felth, Joachim Gullbo, of Uppsala University, Sweden, and colleagues note that cardiac glycosides are a family of naturally-derived drugs used to treat congestive heart failure and abnormal heart rhythms.
Scientists have suspected for some time, based on previous research, that these heart drugs may have promise for fighting many different types of cancer.
However, knowledge on effects in colon cancer or combination effects with other anti-cancer drugs is lacking. Scientists know little about their potential anti-cancer effects and have not tested these substances against colon cancer.
As part of a larger study to screen and identify natural substances with activity against colon cancer, the scientists picked several cardiac glycosides for further study.
They tested five of these heart drugs against laboratory cultures of human colon cancer cells and found that they were all effective, to varying degrees, at killing the cancer cells, says a release of the American Chemical Sociey (ACS).
The sensitivity, however, was rather low when compared to that of other cancer cell types reported previously. Several of the drugs also showed increased anti-cancer activity when combined with certain drugs used for standard chemotherapy.
The findings suggest that these heart drugs may affect colon cancer outcome when used alone or in combination with conventional chemotherapy drugs, they say.
The study is in ACS’ Journal of Natural Products, a monthly publication.
