Washington, Sep 2 (Inditop.com) Humans and chimpanzees are genetically very similar yet clearly distinct in many ways. Scientists have isolated genes that evolved in humans after branching off from other primates, making us uniquely human.
The prevailing wisdom in molecular evolution was that new genes could only evolve from duplicated or rearranged versions of pre-existing genes. It seemed highly unlikely that evolution could produce a functional protein-coding gene from what was once inactive DNA.
However, recent evidence suggests that this phenomenon does occur. Researchers have found genes that arose from non-coding DNA in flies, yeast, and primates.
No such genes had been found to be unique to humans until now, and the discovery raises fascinating questions about how these genes might make us different from other primates.
In this work, David Knowles and Aoife McLysaght of the Smurfit Institute of Genetics at Trinity College Dublin, undertook the painstaking task of finding protein-coding genes in the human genome that are absent from the chimp genome.
Once they had performed a rigorous search and systematically ruled out false results, their list of candidate genes was trimmed down to just three. Then came the next challenge. “We needed to demonstrate that the DNA in human is really active as a gene,” said McLysaght.
The authors gathered evidence from other studies that these three genes are actively transcribed and translated into proteins, but furthermore, they needed to show that the corresponding DNA sequences in other primates are inactive.
They found that these DNA sequences in several species of apes and monkeys contained differences that would likely disable a protein-coding gene, suggesting that these genes were inactive in the ancestral primate.
The authors also note that because of the strict set of filters employed, only about 20 percent of human genes were amenable to analysis.
Therefore they estimate there may be approximately 18 human-specific genes that have arisen from non-coding DNA during human evolution, said a Trinity College release.
What are the proteins encoded by these genes doing? “They are unlike any other human genes and have the potential to have a profound impact,” McLysaght noted.
While these genes have not been characterised yet and their functions remain unknown, McLysaght added that it is tempting to speculate that human-specific genes are important for human-specific traits.
The study was published online in Genome Research.
